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No impairment of renal function has been observed after concurrent administration of large doses of Ceftriaxone and potent diuretics.
There is no evidence to suggest that Ceftriaxone increases renal toxicity of aminoglycosides. The elimination of Ceftriaxone is not altered by probenecid.
Ceftriaxone and chloramphenicol have been shown to be antagonistic in in vitro studies. In cases of concomitant severe renal and hepatic dysfunction, the plasma concentrations of ceftriaxone should be determined at regular intervals.
Coombs test may show false-positive results during Ceftriaxone & Sulbactam therapy. Non-enzymatic urinary glucose estimation methods may give false-positive results.
